• April 8, 2008 at 3:19 am

    Sundowning is not a problem in my household but I came across a thread by PatM located at

    http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/6971035882

    about her use of Melatonin to stop her mother’s sundowning and thought that it might benefit others here. In it she stated that she has been giving her mother 6 mg of Melatolin nightly for 6 weeks. It took 2 weeks for the supplement to kick in…but…Her mother now sleeps through the night. The fact that her mother no longer is belligerent or aggressive during the day is has been an unexpected bonus.

    On the thread she posted the following link that provides information and includes a list of potential side effects.

    http://ezinearticles.com/?Melatonin:-Double-barreled-Weapon-against-Alzheimers-Already-in-Your-Bathroom-Cabinet&id=380641

  • August 17, 2008 at 1:41 am

    Sundowning is still not a problem in my household. A week has not gone by without my reading of someone who tried melatonin out of desperation and got some much needed relief. Many of the postings have described what I consider to be improvements in the cognition of their loved ones.

    The following post from another forum seems to be an indication that my thoughts had a basis in fact. With her permission…I’ve copied and pasted her entire post below. Just for the record…I have not tried melatonin on my loved one and will probably not be in the position to do so for several months.


    INGENTA CONNECT – Journal of Pineal Research
    Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study
    Authors: Furio, Analía M.; Brusco, Luis I.; Cardinali, D. P.

    Source: Journal of Pineal Research, Volume 43, Number 4, November 2007 , pp. 404-409(6)

    Publisher: Blackwell Publishing

    Abstract:: 

    Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome characterized by cognitive impairment preceding dementia. Approximately 12% of MCI patients convert to Alzheimer’s disease (AD) or other dementia disorders every year. In the present report we retrospectively examined the initial and final neuropsychological assessment of 50 MCI outpatients, 25 of whom had received daily 3-9 mg of a fast-release melatonin preparation p.o. at bedtime for 9-18 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin showed significantly better performance in Mini Mental State Examination and the cognitive subscale of the Alzheimer’s Disease Assessment Scale. After application of a battery of neuropsychological tests including Mattis’ test, Digit-symbol test, Trail A and B tasks and the Rey’s verbal test, better performance was found in melatonin-treated patients, except for the Digit-symbol test score which remained unchanged. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with an improvement in wakefulness and sleep quality. The results suggest that melatonin can be a useful add-on drug for treating MCI in a clinical setting.
    Keywords: Alzheimer’s disease; melatonin; minimal cognitive impairment; neuropsychological tests; restrospective study

    Document Type: Research article

    DOI: 10.1111/j.1600-079X.2007.00491.x

    http://www.ingentaconnect.com/content/mksg/jpi/2007/00000043/00000004/art00012?crawler=true

    I have many other studies re potential benefits of melatonin supplementation. If it were a drug — a/k/a “money,” it would be prescribed to everyone with any health problem and particularly those with signs of probable
    neurodegnerative impairment. Take care – Joanne

    Joanne C. Mueller, Guinea Pigs “R” Us, 731 – 123rd Ave. N.W., Minneapolis, MN 55448-2127 USA…Phone: 763-755-6114 ..Email: jcmpelican@aol.com
    WEBSITE: http://guineapigsrus.org